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1994-10-25
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Document 2788
DOCN M94A2788
TI Thalidomide for treatment of aphthous ulcers in patients with HIV.
DT 9412
AU Ball SC; Sepkowitz KA; Jacobs JL; Center for Special Studies, New York
Hospital-Cornell Medical; Center, New York.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):224 (abstract no. PB0327). Unique
Identifier : AIDSLINE ICA10/94369787
AB OBJECTIVE: To examine the efficacy of thalidomide(Tmd) for treatment of
aphthous ulcers(AU) in patients with HIV. METHODS: Case report and
review of the English literature by Medline search. RESULTS: We recently
successfully treated a 31 year old woman with CD4 10/mm and AU
refractory to steroid therapy with 400 mg/d of Tmd. Eight reports from
the literature identified 25 additional patients (22M, 3F) treated with
Tmd for AU. The dose of Tmd ranged from 100-400 mg/day. All patients had
marked improvement. Four (31%) of 13 patients reported relapsed 3 weeks
to 5 months after drug discontinuation. Side effects noted were
drowsiness(4), neuropathy(2) and hypersensitivity(3), all of which
resolved with lowering or discontinuing the dose. CD4 counts reported in
12 patients ranged from 4-372/mm (median 188). CONCLUSION: Our
experience confirms what has been reported in the literature. Although
no placebo-controlled studies have been done, Tmd appears to be useful
in the treatment of AU in patients with HIV. The etiology of AU remains
uncertain. Full evaluation, including viral/fungal cultures and biopsies
should be done on all patients. In carefully monitored patients Tmd may
represent an important treatment option.
DE Adult Drug Evaluation Female Human HIV Infections/*COMPLICATIONS
Male Stomatitis, Aphthous/COMPLICATIONS/*DRUG THERAPY
Thalidomide/ADVERSE EFFECTS/*THERAPEUTIC USE MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).